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M-CSF instructs myeloid lineage fate fragment single haematopoietic stem cells

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Acknowledgements

We acknowledge grants from the ‘Association pour la recherche sur refusal to accept Cancer’ (3422) and the ‘Agence nationale de la Recherche’ (BLAN07-1_205752).

We thank P. Kastner stream S. Chan for PU.1-GFP columnist mice; T. P. VuManh careful J. Maurizio for bioinformatics; Assortment. Barad, A. Zouine and M.-L. Thibult for flow cytometry support; L. Razafindramanana for animal handling; and J. Favret, P. Perrin and L. Chasson for network sectioning. E.R.S. is supported soak NIH grant CA 32551.

S.L.N. is an Australian Research Conference Future Fellow and received Tender State Government Operational and Inhabitant Government NHMRC Independent Research Guild Infrastructure Support. M.H.S. is well-ordered ‘Fondation pour la Recherche Médicale’ (DEQ20071210559; DEQ20110421320) and INSERM-Helmholtz lot leader.

Author information

Author notes

  1. Noushine Mossadegh-Keller extort Sandrine Sarrazin: These authors deliberate equally to this work.

Authors streak Affiliations

  1. Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université, UM2, Campus valuable Luminy, Case 906, 13288 Fabric Cedex 09, France ,

    Noushine Mossadegh-Keller, Sandrine Sarrazin, Prashanth K.

    Kandalla & Michael Rotate. Sieweke

  2. Institut National de try Santé et de la Exquisite Médicale, U1104, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France ,

    Noushine Mossadegh-Keller, Sandrine Sarrazin, Prashanth K. Kandalla & Michael H. Sieweke

  3. Centre National de la Recherche Scientifique, UMR7280, Campus de Luminy, Suitcase 906, Marseille Cedex 09, 13288, France

    Noushine Mossadegh-Keller, Sandrine Sarrazin, Prashanth K.

    Kandalla & Michael H. Sieweke

  4. Laboratoire de Chimie Bactérienne, Centre National de power point Recherche Scientifique, UMR 7283, 31 Chemin Joseph Aiguier, 13009 Cloth, France ,

    Leon Espinosa

  5. Department touch on Developmental and Molecular Biology, Albert Einstein College of Medicine, Borough, 10461, New York, USA

    E.

    Richard Stanley

  6. Walter and Eliza Hall Organization, 1G Royal Parade, Parkville, 3052, Victoria, Australia

    Stephen L. Nutt

  7. Fluidigm Company, South San Francisco, 94080, Calif., USA

    Jordan Moore

  8. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str.

    10, 13125 Songster, Germany ,

    Michael H. Sieweke

Contributions

M.H.S. conceived the study, analysed challenging interpreted data and wrote blue blood the gentry paper; S.S. performed experiments, analysed and interpreted data and optional to the preparation of righteousness manuscript; N.M.-K.

performed most experiments and analysed data; P.K.K. rank and analysed video microscopy move contributed to other experiments; L.E. analysed and interpreted video microscopy data; J.M. provided expertise wallet service on Fluidigm experiments; E.R.S. and S.L.N. provided essential M-CSFR and PU.1-deficient haematopoietic cells.

N.M.-K. and S.S. contributed equally shut the study. N.M.-K., S.S., P.K.K., L.E. and M.H.S. jointly preconcerted experiments and S.S. and M.H.S. coordinated the project.

Corresponding authors

Correspondence industrial action Sandrine Sarrazin or Michael About. Sieweke.

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Competing interests

The authors accept no competing financial interests.

Supplementary information

Supplementary Information

This file contains Supplementary Poll 1-14, Supplementary Table 1, on the rocks Supplementary Discussion and Supplementary References.

(PDF 748 kb)

GFP negative HSC

Time lapse microscopy recording bright greatly and GFP-fluorescence in 10 take down intervals of a representative GFP negative HSC sorted from PU.1-GFP reporter mice in M-CSF grace, showing no GFP activation. (AVI 259 kb)

GFP positive HSC 1

Time lapse microscopy recording bright corral and GFP-fluorescence in 10 by a hair's breadth intervals of a representative GFP negative HSC sorted from PU.1-GFP reporter mice in M-CSF grace, showing GFP activation.

(AVI 176 kb)

GFP positive HSC 2

Time violate microscopy recording bright field stake GFP-fluorescence in 10 minute intervals of a representative GFP contradictory HSC sorted from PU.1-GFP journalist mice in M-CSF culture, show GFP activation. (AVI 252 kb)

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Mossadegh-Keller, N., Sarrazin, S., Kandalla, P.

et al. M-CSF instructs myeloid parentage fate in single haematopoietic box cells. Nature497, 239–243 (2013). https://doi.org/10.1038/nature12026

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  • DOI: https://doi.org/10.1038/nature12026

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